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FDA Assessment FDAs 2026 briefing described major characterisation, effectiveness and safety limitations and proposed against inclusion on the 503A Bulks List

While nicotine itself is not considered to be carcinogenic, each cigarette contains a mixture of carcinogens, including a small dose of polycyclic aromatic hydrocarbons (PAHs) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) among other lung carcinogens, tumor promoters, and co-carcinogens

Progestin-only pills or mini pills are not effective and may worsen acne

Liver transaminase and myocardial enzymes were increased with abnormal coagulation function