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Current state of the art of mass spectrometry-based metabolomics studies a review focusing on wide coverage, high throughput and easy identification

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Figure 1(II) demonstrates rats with FM induced by Reserpine presented an exacerbation in the urged pain response, as noted by the aberrations in the nociceptive reflexes through the decremented threshold of (A) the von Frey test (VFT) and (B) CAPWL, reaching 71% [F (2,27) = 6.376, p = 0.0053, 2 = 0.321] and 40% [F (2,27) = 20.12, p = 0.0003, 2 = 0.770], respectively, compared to the normal rats

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