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Available at: (Accessed: 27 February 2026) These side effects have been demonstrated in clinical trials and are relatively well-established
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Hamadjida A, Nuara SG, Bdard D, Gaudette F, Beaudry F, Gourdon JC, Huot P (2018) The highly selective 5-HT2A antagonist EMD-281,014 reduces dyskinesia and psychosis in the l-DOPA-treated parkinsonian marmoset
Where it works: Adipose tissue (fat cells): Reduces inflammation and may improve fat metabolism Pancreas: Works alongside GLP-1 to enhance insulin secretion Brain: May contribute to appetite regulation (research ongoing) Weight loss contribution: When GIP is added to GLP-1 (as in tirzepatide), weight loss increases from ~15% to ~22%
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