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Furthermore, the CRL5 complex can prevent Src-induced transformation of mammary epithelial cells by promoting the ubiquitination and degradation of p130Cas (also known as Breast Cancer Anti-estrogen Resistance protein 1, BCAR1) (161)

Inhibiting hepcidin expression enables macrophages to excrete excess iron and cholesterol, thereby reducing foam cell formation and atherosclerosis progression (52)

Signals are compelling enough to demand conversation and monitoring, even if definitive rules are not established

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