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Thus, it has been suggested that GLP-1R signaling could interact with the somatotropic axis [15] and potentially be a regulator of linear growth

Incretin mimetics, such as exenatide, are functional analogs of glucagon-like peptide-1 (GLP-1), a naturally occurring peptide that has the potential to significantly improve glycemic control in patients with diabetes

GLP-1R expression has also been demonstrated in the central nervous system 45 (CNS), but it is unlikely that such a large molecule as MEDI4166 can efficiently cross the blood brain barrier