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The stimulation of the 7nAChR has been shown to exert anti-inflammatory effects by inhibiting cytokine production and release, such as TNF-, which is neurotoxic, by microglia (97, 98)

The list of modulated proteins was used to investigate the molecular pathways altered in GCSCs by String 9.0 analysis

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27 Importantly, GLP-1 action is short-lived, with a half-life of just 12 minutes in the bloodstream under normal physiological conditions, after which it is broken down by the enzyme dipeptidyl peptidase IV (DPP-4), resulting in a loss of its biological activity