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AMG 133 results in full agonism of human GLP-1R (EC 50 = 24.4 pM) and activated cynomolgus monkey and mouse GLP-1R (EC 50 of 5.7 and 123 pM, respectively)

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This was a randomized, head-to-head comparison that enrolled 751 individuals and found those who took tirzepatide lost 20% of their body weight, about 50 pounds on average, while those on semaglutide lost 14% of their body weight, or about 33 pounds on average