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The reduced model (Figure 2A) is crucial in that it contains all of the components that are relevant to the dynamics of the methionine cycle even when excised from the full network

doi: 10.1038/s12276-023-00971-9 36 GaoPTchernyshyovIChangT-CLeeY-SKitaKOchiTet al

Combination therapies that modestly lower ferroptosis thresholdsrather than forcibly collapsing antioxidant capacitymay provide a practical route to achieve efficacy with tolerable toxicity