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The ratios of [H]/[C] CPM/Gram consistently exceeded that observed in blood, confirming Dihexas ability to cross the BBB
Male rats were used over female rats in order to eliminate any skewed data that may result from hormonal fluctuations related to the rats reproductive cycles
Dihexa Based on 6 publication(s) in Google Scholar Dihexa, an oligopeptide drug, is an orally active and blood-brain barrier-permeable angiotensin IV analog
The introduction of wortmannin was found to significantly reverse the expression of PI3K and AKT, as well as the anti-apoptotic and anti-inflammatory effects of Dihexa, resulting in a decrease in the number of neuronal cells present in the cortex and the levels of IL-10, and an increase in the levels of TNF-alpha and IL-1-beta [1]
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