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IV protocols require more careful titration

[14] Local IGF-1 isoforms, mechanical loading, satellite-cell dynamics, and myostatin signaling together form the regulatory web within which any exogenous IGF-1 agonist would be acting another reason that predicting the whole-organism effect of an isolated analog from single-pathway experiments is unreliable

As described in the same source, This is why the body needs to metabolise your muscles when youre in a calorie deficit. Early in a calorie deficit, the body first uses glycogen stores for energy