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When intake is frequent, doses accumulate, or detox capacity is impaired, glutathione becomes depletedallowing NAPQI to build up and trigger liver cell injury and death (17)

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201 This evidence reinforces the role of micropinocytosis as a route for the import of different compounds (proteins), to be used as nutrients or signalling molecules in cancer promotion

doi: 10.1016/j.freeradbiomed.2009.12.022