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Ethics statement The studies involving human participants were reviewed and approved by Institutional Review Board at Nova Southeastern University in Fort Lauderdale, FL, USA

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At the cellular level, everolimus has been demonstrated to enhance autophagy by inhibiting PI3K/Akt/mTOR pathway

Importantly, elevated KYNA in the CNS may contribute to cognitive deficits in schizophrenia by antagonizing 7nAChRs and NMDARs, which are critical for synaptic plasticity, working memory, and cortical network coordination [76, 240,241,242]