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But because the landscape around compounded GLP-1 medications has shifted dramatically since the FDA resolved the semaglutide shortage in February 2025, and what was once a straightforward decision now involves regulatory gray areas, legal battles, and quality control questions that most people never expected to navigate

Commonly involved suctioned areas include the anterior part of the neck (under the chin), upper arms, male chest/breasts (gynecomastia), trunk, abdomen, waist, hips, inner and outer thighs, and inner knees

The authors provide an overview of general principles and theoretic advantages and disadvantages

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