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Jabbour AM, Heraud JE, Daunt CP, Kaufmann T, Sandow J, OReilly LA, Callus BA, Lopez A, Strasser A et al (2009) Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim

A B12 deficiency can result in fatigue, weakness, memory problems, and even more severe health issues such as anaemia or neurological damage if left untreated

The escalation periods built into GLP-1 protocols allow gastrointestinal adaptation that prevents severe nausea and other side effects

They will consider various factors such as the individuals medical condition, other medications being taken, and any specific considerations for optimal dosing