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No adverse reactions, such as scarring or infection, were observed in the subjects

Although ED it is not a life-threatening disease, therapeutic management of ED should not be overlooked, since ED may negatively impact on couple relationship and general health, and even moderate improvements of vascular dysfunction might have a significant clinical impact

Furthermore, an additional study has elucidated that lactate activates antioxidant defense and pro-survival pathways, including the unfolded protein response and nuclear factor erythroid 2-related factor 2 (NRF2) signaling cascades, by inducing mild oxidative stress in neuroblastoma cells (100)

Visser, M., van der Stoep, N