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Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy

In HeLa cells, GPX8 is enriched in mitochondria-associated membranes (MAMs), a critical integrating center for calcium, lipid metabolism, and redox signaling homeostasis

Because the lingering viral fragments, persistent endothelial damage, or subsequent immune dysregulation prevents glutathione levels from naturally rebounding to baseline, ROS continue to accumulate unchecked throughout the body

H., Petrovic, A., Sikiric, S., Vranes, H., Prtoric, A., Zizek, H., Durasin, T., Dobric, I., Staresinic, M., Strbe, S., Knezevic, M., Sola, M., Kokot, A., Sever, M., Sikiric, P