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Further adequately powered prospective studies are required before combined SGLT2 inhibitor and GLP-1 receptor agonist therapy can be routinely recommended, specifically to improve heart failure outcomes

Extensive persistent inflammation even when SARS-CoV-2-infected cells are only sporadically present at late stages of COVID-19 (Schurink et al., 2020) could also justify low GSH levels in association with over-abundance of cellular ROS, cellular oxidative damage, increased inflammation and cell death pathways activation seen in inflammaging (Zuo et al., 2019