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Common Side Effects Nausea (very common approximately 40% of patients) Flushing Injection site reactions: pain, redness, bruising Headache Vomiting Cough Fatigue Hot flush Skin hyperpigmentation (focal dark patches, especially with repeated use) Seek Immediate Medical Attention For Severe, persistent increase in blood pressure Chest pain, shortness of breath, or irregular heartbeat Signs of severe allergic reaction Persistent or worsening skin darkening Drug Interactions Naltrexone: Bremelanotide may significantly decrease naltrexone exposure, potentially reducing its effectiveness for alcohol/opioid use disorder treatment Orally administered medications: Slowed gastric emptying may affect absorption of other oral drugs Use in Pregnancy Bremelanotide is contraindicated in pregnancy

Timing: MOTS-C is often timed around physical activity to mimic its natural release

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Some people who take Rybelsus do lose weight, however the amount is usually less than what is seen with injectable medications like Wegovy or Ozempic