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In a mouse aging model induced by D-galactose, Polygonatum sibiricum Redout polysaccharide regulates the function of mitochondria-associated membranes (MAMs) by downregulating the expression of key proteins such as IP3R, GRP75, and VDAC1, as well as decreasing the expression of the mitochondrial calcium uniporter (MCU), maintaining intracellular calcium homeostasis (99)