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Furthermore, long-acting GLP-1 RAs induce prolonged exposure with effective GLP-1 RA concentrations and maintained over 24h or a week [21], reduce HbA1c more efficiently and cause similar weight reduction compared with short-acting GLP-1 RAs [20], incretins that cause a sharp rise in drug concentrations postinjection that decrease to lower levels after reaching the maximum limit within a few hours [22]

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