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Importantly, recent studies aimed at blocking the metaorganismal TMAO pathway through multiple approaches have confirmed the inhibition of diet-dependent atherosclerosis in animal models, either by targeting the initial microbial formation of TMA from choline through use of a nonlethal small-molecule inhibitor (19), or by targeting the second step in the pathway, the major host gene responsible for converting microbe-generated TMA into TMAO, flavin monooxygenase 3 (20, 21)

They also reported no difference in NASH resolution between groups (34% vs

10.1016/j.phymed.2024.155646 109 MeihuaJ.ChunW.YifengX.ZijingZ.XueyanW.RunfaY.et al (2022)

Importantly, liposomal vitamin C avoids the gastrointestinal intolerance seen with high-dose conventional vitamin C, making it suitable for long-term use