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The researchers utilized advanced mass spectrometry and RNA-sequencing to map the exact metabolic dysfunctions driving these conditions, uncovering striking evidence of severe oxidative stress and mitochondrial lipid oxidative damage mediated by glutathione peroxidase 4, as documented in the PNAS metabolic study

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Thus, using SCENIC + , we constructed a regulatory network from our single-nuclei multiomic dataset which showed enrichment of PPARA and RXRA

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