It may be set in early adolescent life but clinically manifests in childbearing age with long-term complications such as type 2 diabetes mellitus, hypertension, hyperlipidemia, endometrial cancer, and cardiovascular disorders [4]
However, in a double-blind, placebo-controlled trial in 32 healthy adults, propionyl-L-carnitine (1 g/day or 3 g/day) for eight weeks did not improve aerobic or anaerobic exercise performance (130)
These findings support the rationale for frequent, low-dose supplementation strategies in healthy individuals, while also emphasising the need for personalised approaches in those with malabsorption syndromes (Bor et al., 2010)
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