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Among scores of enthusiasts online, fitness TikToker Noah Jay claimed in a recent video that the peptide BPC-157 healed his shoulder injury: "I absolutely love this stuff!" Like many influencers talking up peptides, his profile links to a discount code for an online retailer

PMID: 77 XuJXuHLiJHuangWLiYGuoXet al

Its defining structural feature is the gamma-glutamyl linkage: the glutamate residue is joined through its side-chain carboxyl rather than the usual alpha-peptide bond, which makes the molecule resistant to most intracellular peptidases and means it is cleaved almost exclusively by gamma-glutamyl transpeptidase at the outer cell surface (Zhang, Forman and Choi, Methods in Enzymology, 2005)