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Such panels can test NOX inhibition (isoform-specific), mitochondrial modulators (improving biogenesis/mitophagy, tempering RET and Ca overload), iron management (chelators, ferritinophagy restraint) and RSS augmentation (controlled H 2 S/persulfide donors) designed to preserve physiological H 2 O 2 signalling needed for plasticity while reducing nitrative and Fenton chemistry that drives irreversible injury (Li et al