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Importantly, pretreatment with ferrostatin-1 and deferoxamine attenuated Apis efficacy on NCI-H929 cells by over threefold, strongly suggesting the potential involvement of ferroptosis-related pathways in Api-mediated MM cell death

As a result, people often turn to the use of supplements that contain both compounds

A primary constraint is the significant methodological heterogeneity and lack of reproducibility of the existing studies