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Reviewing publications that also included cases reported before the 2021 WHO classification revealed equivocal treatment results

Thats because doctors tend to start people out on a low dose and gradually increase it over time, partly to help offset some of the side effects

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Oral administration of high-dose vitamin B 12 (1 to 2 mg daily) is considered as effective as intramuscular administration for correcting anemia and neurologic symptoms Despite many studies suggesting oral administration of vitamin B 12 to be easy, effective and less costly than intramuscular administration, debate surrounds the effectiveness of the oral route