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Mechanism of Action L-Carnitine transfers long chain FAs into the mitochondria Required for Energy Production Evidence of Benefits Orer & Guzel Double-blind study examined L-Carnitinesupplementation on endurance performance of professional soccer players 2 groups: 1 received 3g L-Carnitine, 1 received 4g Exercise test: Running at 10km/hr, increasing 1 km/hr every 3 minutes Heart rate, Lactic Acid concentrations, & perceived level of difficulty were measured The test was performed using a placebo, 1 week later Results of the study L-carnitine supplementation increased the effectiveness of endurance performance Heart rate decreased Lactic Acid Concentrations decreased Running speeds increased Exhaustion was prolonged (perceived level of difficulty) Conflicting Research Colombani et al Double-blind study examined the effect of L-Carnitine supplementation on the performance of marathon runners Results No significant change in marathon running time L-Carnitine did not improve physical performance Safety Concerns No serious toxicity has been reported With doses over 6000mg: Nausea Vomiting Diarrhea Professional Position L-carnitine is proven to be effective in the treatment of many diseases, & generally safe and non-toxic if taken in doses less than 6g Though there seems to be inconsistent evidence in its effectiveness of exercise performance, there is a greater possibility of benefits References Colombani, P

In mouse and rat models of choline and methionine-deficient diet-induced metabolic dysfunction-associated steatotic liver disease (MASLD), females are reported to be more protected than their male counterparts 88

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