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A prior late-stage trial published in December showed the drug helped obese or overweight patients with one or more comorbidities, but not type-2 diabetes, lower their weight by 22.7% after 68 weeks, also below the 25% expected

Tirzepatide offers slightly more dosing flexibility: While it also follows a stepup plan, tirzepatide provides more options for adjusting doses based on an individuals tolerance and response

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Many people take one of these injections alongside metformin, and the main head-to-head trials were done in people already using metformin