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6 Obesity-related hypothalamic inflammation and proinflammatory cytokine production can lead to suppression of leptin signaling and failure to feel the sensation of being full, known as leptin resistance

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However, identifying responsive tumor subpopulations remains a major obstacle in developing metabolism-targeted therapies, as metabolic vulnerabilities vary among cancers with different oncogene expression profiles

Green synthesis of CaO nanoparticles improves their compatibility with human cells and incorporates phytochemicals that provide additional anticancer effects, thereby addressing challenges associated with standardization, stability, and toxicity