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As a 2026 review noted, the original composition-of-matter patents "have likely expired reducing the commercial exclusivity that typically incentivizes industry-sponsored Phase II and III development" [13]

It tends to decrease with subsequent injections at the same dose as your body adapts

In this two-tier screening approach, BBB-PAMPA was first employed to eliminate compounds with poor passive permeability, followed by MDR1-MDCK I to screen out P-gp efflux transporters' substrates