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Alteration of several metabolic enzymes and pathways that affect KG abundance and KGDD activity have been reported in cancer, such as mutations of the genes encoding isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2), changes in glutaminolysis that deplete KG, and alterations in fumarate hydratase and succinate dehydrogenase that inhibit KGDD activity 11

B vitamins .Low levels of B vitamins have been associated with increased blood levels of homocysteine, a toxic amino acid linked to heart disease risk

Smaller molecules like 5-Amino-1MQ target the NNMT enzyme pathway to shift fat cell metabolism from storage to burning

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