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Disorders of muscle lipid metabolism: diagnostic and therapeutic challenges

doi: 10.3389/fphar.2025.1689575 Received 20 August 2025 Revised 22 October 2025 Accepted 27 October 2025 Published 21 November 2025 Volume 16 - 2025 Edited by Mamunur Rashid, University of Nebraska Medical Center, United States Reviewed by Franois Trottein, Institut Pasteur de Lille, France Yunlei Zhang, Nanjing Medical University, China Updates Copyright 2025 Ruan, Lin, Lin, Zhan, Zheng, Lin, Zhuang and Zeng

Low NAD+ links to age-related diseases like cardiovascular issues, metabolic disorders, neurodegeneration, and cancer.[3][16] For example, in Alzheimer's models, NAD+ depletion exacerbates amyloid plaque formation and neuronal death