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To combat oxidative stress, iPSCs employ a sophisticated antioxidant defense system, including superoxide dismutase and glutathione peroxidase, which are essential for protecting cells from ROS-induced damage [100]

The PSM was performed using 1:1 to reduce the confounding effects

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PAGln inhibits myocardial contraction via 2AR signaling, while concurrently activating pathways that exacerbate oxidative stress, calcium dysregulation, and electrophysiological abnormalities, ultimately accelerating thrombosis and structural remodeling