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Long-lasting modulation targeting different genotypes leads to different changes in synaptic plasticity [68], which could be an important strategy for sustained antidepressant effect

the number of ROS produced by damaged mitochondria may exceed the processing capacity of the mitophagy machinery, and in some cases, mitophagy may even promote cell death

doi: 10.1038/s41423-021-00661-4, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 30

Therefore, future research must prioritize large-scale, long-term (2 years) RCTs employing standardized EPA/DHA formulations and doses targeted to achieve specific tissue or plasma levels