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When there were studies with the high risk of bias, and exclusion of such study resulted in different outcome, then present them into the sensitivity analysis at the section 3.7

Additionally, while both laboratory and prescription dispensing data are captured in Optum CDM, indication information was not available and data were generated from healthcare delivery rather than for research purposes and may therefore be incomplete or missing

Lepore JJ, Olson E, Demopoulos L et al (2016) Effects of the Novel Long-Acting GLP-1 Agonist, Albiglutide, on cardiac function, cardiac metabolism, and exercise capacity in patients with chronic heart failure and reduced ejection fraction

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