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Variants at these sites, specifically R471C/H/P and Y358N, are implicated in the carnitine disorder SPCD 49

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Proliferation assay 1919 isogenic cells, MDA-MB-468 BRCA PHGDH wild type cells and MDA-MB-231 BRCA cells characterized by PHGDH amplification were seeded (7500 cells/well) in 96-well plates (Sigma-Aldrich) and incubated at 37 C for 24 h to obtain optimal adherence to the surface

Single-Use Vials vs Multi-Dose Vials The intended dosing schedule is the most practical factor in choosing between the two solutions