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Metal chaperones such as CQ and PBT2, which maintain metal ion homeostasis, have been shown to restore cognition, elevate zinc levels in the hippocampus, and restore levels of key proteins involved in learning/memory and synaptic plasticity in ZnT3 knockout mice

Lean body mass was determined using DXA scans (London X-ray clinic, London, ON) by trained technicians

Agmatine as a novel candidate for rapid-onset antidepressant response