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Limited bioavailability and BBB penetration, reducing their central nervous system efficacy

Elevation of mouse kidney thiol content following administration of glutathione

Am J Pathol 190(4):844861 Francis R et al (2020) Glycolytic inhibitor 2-deoxyglucose suppresses inflammatory response in innate immune cells and experimental staphylococcal endophthalmitis

Clinical studies on oral glutathione often use doses of 500-1,000mg as in a four-week trial in 2011 and another in 20192 3 but we know that effective doses have ranged as low as 250mg, like in a six-week trial of Setria (the same brand used in Codeage) in 2015.4 Because Codeage delivers 500mg of Setria across two capsules, you can take the lower dose if youre concerned about the safety issues that may correspond with higher doses,5 or you can take the full recommended serving size if youre not