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However, a needed framing of this question is not whether GLP-1 medications induce SMM loss at all, but rather does greater SMM loss occur as compared to the normal degree of SMM loss that occurs with other weight loss interventions
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The review would benefit from a bit more text on how this notion impacts the balance between desired therapeutic effects, "diluted" effects from dimer-mediated versus non-dimer effects, and undesired off-target effects (which are discussed some in terms of receptor specificity, but not in terms of anatomy, where the same dimer may have different effects in different brain regions). Response: We have added a new section title General treatment approaches before the concluding remarks
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