retatrutide vs orforglipron vs PlexusDx (2026) Orforglipron vs Retatrutide | Ageless

On Wegovy (semaglutide 2.4 mg, approved for chronic weight management): The FDA-approved prescribing information for Wegovy discloses that in the SELECT cardiovascular outcomes trial - a large study conducted in adults with established cardiovascular disease - hip and pelvis fractures were reported more often in female patients on Wegovy than in those on placebo: 1% (24/2,448) versus 0.2% (5/2,424)

Reliable dosing plus steady adherence produces stronger, steadier weight loss

Retatrutide is not yet FDA approved, but like many GLP-1 agonists such as Wegovy (semaglutide) and Mounjaro (tirzepatide), retatrutide will most likely be a weekly injection, delivered subcutaneously into the arm, thigh or stomach area in a self-inject pen

Exenatide represents an artificial 39-amino-acid version of exendin-4 derived from Gila monster venom, which contains roughly 50% sequence similarity to human GLP-1