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Unfortunately, according to the authors, curcumin does all of these and more

No GLP-1 supplements use GRAS (Generally Recognized As Safe) ingredients and are regulated as dietary supplements, not FDA-approved drugs

Metformin makes muscle cells more sensitive to insulin, allowing more glucose to move from the bloodstream into the muscles

The absence of such evidence means that healthcare professionals cannot reliably predict how these drugs might interact, whether they would provide additive benefits, or what adverse effects might emerge from their concurrent use