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Moreover, long-term exposure of these AEDs often triggers adverse effects including hepatic injury and renal toxicity, cognitive deficit and psychiatric abnormalities [25]

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More recently, urea-based and pyrazolidine CypD inhibitors with nanomolar affinity have shown robust protection of pancreatic mitochondria and tissue architecture in cerulein- and bile acid-induced AP, confirming that mPTP inhibition is a druggable node that functionally stabilizes mitochondrialER Ca 2+ crosstalk, ROS generation, and cell-death patterns

Favorable effects of L-carnitine treatment on hypertriglyceridemia in hemodialysis patients: decisive role of low levels of high-density lipoprotein-cholesterol