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It plays a key role in transporting long-chain fatty acids to the mitochondria, the small powerhouses found in every cell which enable energy to be produced in the form of adenosine triphosphate (ATP)

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This introduces clinical heterogeneity and considerably attenuates the practical interpretation of pooled estimates, given the well-established beneficial effects of GLP-1 RAs in reducing both HbA 1c and body weight, as opposed to the neutral effect of a placebo intervention [4,5,6]