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2D classification showed clear secondary structure features and random distribution of particles in different directions enabling high-resolution cryo-EM map reconstruction (Supplementary information, Fig

Description IGF-DES (Des(1-3) IGF-1) IGF-DES, also known as Des(1-3) IGF-1, is a truncated analog of insulin-like growth factor-1 lacking the first three N-terminal amino acids that researchers have identified as significantly more potent than full-length IGF-1 due to reduced binding to IGF binding proteins (IGFBPs)

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