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In contrast, a multicenter retrospective cohort study, including a higher-risk population (23% with CKD) reported slower eGFR decline and lower risks of CKD progression and doubling of serum creatinine among SGLT2 inhibitor users compared with GLP-1 receptor agonist users
The headline numbers from the phase 2 obesity trial were striking: the highest dose group averaged 24.2% body weight reduction at 48 weeks, far ahead of what any single-mechanism drug had managed
In a nutshell, the number you see on the weighing scale doesnt distinguish between fat loss and muscle loss, nor does it tell you how your body composition is changing
When I looked at the dietary adherence data from similar GLP-1 trials, participants consistently reported that following a calorie deficit felt easier on the drug than off it
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