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*Correspondence: Zhigang Ren, [email protected] Yu, [email protected] These authors have contributed equally to this work This article was submitted to Signaling, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

50 This finding not only strengthens the concept that oxidative stress indeed is not only the key factor in determining the degree of endothelial dysfunction but also that it impacts the prognosis of patients with established atherosclerosis

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