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A review of over 300 casecontrol and cohort studied used final height as an indication of GHIGF-1 action and found that individuals over 175 cm have a 20% higher chance of developing prostate cancer, a 22 and 2060% higher chance of breast and colorectal cancers, respectively, when compared with individuals below 160 cm (278, 279)

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J Clin Invest (2010) 120(11):400720.10.1172/JCI42447 265 ListEOBerrymanDEFunkKGosneyESJaraAKelderBet alThe role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice

GH/IGF-1 in Aging and Age-Related Diseases Circulating GH/IGF-1 levels peak in the second decade of life (242, 243) with this axis being the main regulator of postnatal growth while modulating other important physiological processes as well (244)