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In non-flavonoid polyphenols, there is clear evidence that epigallocatechin gallate (EGCG), curcumin, and anthocyanins promote physical endurance, although the effects are different

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The mechanistic core of the finding was that Dihexa activated the PI3K/AKT signaling pathway in the brains of the APP/PS1 mice, and that the PI3K inhibitor wortmannin reversed Dihexas anti-inflammatory and anti-apoptotic effects [5]