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2022;28:591598F

These effects are seen even outside of diabetes control.[ref] Decreased colon cancer mortality: A 5-year mortality study in colon cancer patients showed that GLP-1 RA use decreased mortality risk by 60% in obese patients.[ref] Decreased risk of substance abuse: A large 2026 study using data from the VA showed that GLP-1 RA drugs reduce the risk of developing a substance addiction (drugs, alcohol)

Controlled studies have reported changes in glucose-related biomarkers and metabolic signaling endpoints, which researchers use to investigate how combined receptor engagement may alter endocrine pathway activity in experimental systems [2][3][5]

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